Effect of Tetrabenazine on the Striatal Uptake of Exogenous L-DOPA in Vivo: A PET Study in Young and Aged Rhesus Monkeys
Physics and Astronomy
The effect of tetrabenazine (TBZ) pretreatment on the striatal uptake of exogenous L-DOPA in vivo was assessed noninvasively in rhesus monkeys by positron emission tomography (PET) using the tracer [18F]-FluoroDOPA (FDOPA). Paired studies were done comparing baseline vs. TBZ treatment on the uptake of FDOPA, a measure of aromatic L-amino acid decarboxylase (AAAD) activity. Results show increased AAAD activity with TBZ treatment. These results suggest that the action of TBZ as a dopamine antagonist dominates more than its expected action as a potent vesicular monoamine transporter (VMAT2) inhibitor. Results also showed diminished responsivity of AAAD to TBZ challenge in aged monkey brain.
O.T. DeJesus, S.E. Shelton, A.D. Roberts, R.J. Nickles, and J.E. Holden. (2002). Effect of Tetrabenazine on the Striatal Uptake of Exogenous L-DOPA in Vivo: A PET Study in Young and Aged Rhesus Monkeys. Synapse, 44(4), 246-251.
Publisher's Copyright and Source
Copyright © 2002 Wiley-Liss, Inc. Article published by John Wiley & Sons in Synapse, volume 44, issue number 4, June 2002, pages 246-251. Available online on March 22, 2002: http://dx.doi.org/10.1002/syn.10077