Sensory Processing Disorder in a Primate Model: Evidence From a Longitudinal Study of Prenatal Alcohol and Prenatal Stress Effects
Physics and Astronomy
Disrupted sensory processing, characterized by over- or underresponsiveness to environmental stimuli, has been reported in children with a variety of developmental disabilities. This study examined the effects of prenatal stress and moderate-level prenatal alcohol exposure on tactile sensitivity and its relationship to striatal dopamine system function in thirty-eight 5- to 7-year-old rhesus monkeys. The monkeys were from four experimental conditions: (a) prenatal alcohol exposed, (b) prenatal stress, (c) prenatal alcohol exposed + prenatal stress, and (d) sucrose controls. Increased D2 receptor binding in the striatum, evaluated using positron emission tomography neuroimaging, was related to increased withdrawal (aversion) responses to repetitive tactile stimuli and reduced habituation across trials. Moreover, prenatal stress significantly increased overall withdrawal responses to repetitive tactile stimulation compared to no prenatal stress.
M.L. Schneider, C.F. Moore, L.L. Gajewski, J.A. Larson, A.D. Roberts, A.K. Converse, and O.T. DeJesus. (2008). Sensory Processing Disorder in a Primate Model: Evidence From a Longitudinal Study of Prenatal Alcohol and Prenatal Stress Effects. Child Development, 79(1), 100-113.
Publisher's Copyright and Source
Copyright © 2008 the Society for Research in Child Development, Inc. Article published by John Wiley & Sons in Child Development, volume 79, issue number 1, January/February 2008, pages 100-113. Available online on February 4, 2008: http://doi.org/10.1111/j.1467-8624.2007.01113.x.