Simultaneous Dual Tracer PET Imaging of Alterations in Dopamine D2 Receptor Occupancy and Blood Flow in Rat Brain
Physics and Astronomy
To search for evidence of dopaminergic neuromodulation, we are developing a method for correlating dopamine release in regions of high D2 receptor density and blood flow alteration in regions throughout the brain. If variations in dopamine receptor ligand binding (delta-BP) and blood flow (delta-rCBF) are measured separately, then intra-individual inter-scan variation is expected to reduce the precision of such correlations, especially in studies of humans performing tasks. Therefore, we seek to simultaneously measure delta-BP and delta-rCBF in response to an intervention. Here, we describe progress in methodological development using anesthetized rats responding to a pharmacological challenge.
Poster presented at Neuroreceptor Mapping 2006, The Sixth International Symposium on Neuroreceptor Mapping in Copenhagen, Denmark, July 6-8, 2006.
A.K. Converse, J.M. Moirano, N.T. Vandehey, D. Murali, L.G. Flores, T.R. Oakes, J.E. Holden, A.D. Roberts, T.J. Ruth, O.T. DeJesus, R.J. Nickles, and R.J. Davidson. (2006). Simultaneous Dual Tracer PET Imaging of Alterations in Dopamine D2 Receptor Occupancy and Blood Flow in Rat Brain. NeuroImage 31 (Supplement 2), T59.
Publisher's Copyright and Source
Copyright © 2006 Elsevier. Article published by Elsevier in NeuroImage, volume 31, Supplement 2, 2006, page T59. Available online June 29, 2006: http://doi.org/10.1016/j.neuroimage.2006.04.050.