[11C]raclopride Imaging of Dopamine Release in Rhesus Monkeys
Physics and Astronomy
For a variety of purposes we have begun implementation of a PET method for studying dopamine release. We used the dopamine D2-type receptor antagonist [11C]raclopride to study dopamine function in the rhesus monkey brain in response to an amphetamine challenge. [11C]raclopride is susceptible to competition from endogenous dopamine, whereby dopamine released into extracellular space reduces the number of binding sites available for the tracer.
Journal of Cerebral Blood Flow & Metabolism
A.K. Converse, T.E. Barnhart, C.B. Dallas, S. Jivan, J.A. Larson, T.R. Oakes, A.D. Roberts, T.J. Ruth, N.T. Vandehey, and M.L. Schneider. (2005). [11C]raclopride Imaging of Dopamine Release in Rhesus Monkeys. Journal of Cerebral Blood Flow & Metabolism, 25(S1), S647.
Publisher's Copyright and Source
Copyright © 2005 International Society for Cerebral Blood Flow & Metabolism. Abstract published by Nature Publishing Group in Journal of Cerebral Blood Flow & Metabolism, volume 25, supplement 1, 2005, page S647. Available online on August 30, 2005: http://doi.org/10.1038/sj.jcbfm.9591524.0647.