Title

[11C]raclopride Imaging of Dopamine Release in Rhesus Monkeys

Document Type

Conference Abstract

Publication Date

2005

Department

Physics and Astronomy

Abstract

For a variety of purposes we have begun implementation of a PET method for studying dopamine release. We used the dopamine D2-type receptor antagonist [11C]raclopride to study dopamine function in the rhesus monkey brain in response to an amphetamine challenge. [11C]raclopride is susceptible to competition from endogenous dopamine, whereby dopamine released into extracellular space reduces the number of binding sites available for the tracer.

Publication Title

Journal of Cerebral Blood Flow & Metabolism

DOI

10.1038/sj.jcbfm.9591524.0647