Production of [17F]CH3F(t1/2=65s), an Improved PET Tracer for rCBF Measurement
Physics and Astronomy
Production of 17F (t1/2=65s) in the form of [17F] F2 has been achieved using both the 20Ne(p,α)17F and 16O(d,n)17F reactions with 11 MeV protons and 6 MeV deuterons, respectively. Yields have proven suitable for subsequent radiosynthesis of the blood flow tracer, [17F]CH3F (>60 mCi in saline), currently in use for fast repetition human studies of regional cerebral blood flow with positron emission tomography. Thick target yields of 15 mCi/μA for protons and 44 mCi/μA for deuterons have been measured for [17F]F2.
Applied Radiation and Isotopes
T.E. Barnhart, A.K. Converse, K.A. Dabbs, M.J. Schueller, C.K. Stone, R.J. Nickles, and A.D. Roberts. (2005). Production of [17F]CH3F(t1/2=65s), an Improved PET Tracer for rCBF Measurement. Applied Radiation and Isotopes, 62(4), 525-532.
Publisher's Copyright and Source
Copyright © 2004 Elsevier Ltd. Article published by Elsevier in Applied Radiation and Isotopes, volume 62, issue number 4, April 2005, pages 525-532. Available online on September 21, 2004: http://doi.org/10.1016/j.apradiso.2004.08.044.