Once-a-Day Concerta Methylphenidate versus t.i.d. Methylphenidate in Laboratory and Natual Settings
Methylphenidate (MPH), the most commonly prescribed drug for attention-deficit/hyperactivity disorder (ADHD), has a short half-life, which necessitates multiple daily doses. The need for multiple doses produces problems with medication administration during school and after-school hours, and therefore with compliance. Previous long-acting stimulants and preparations have shown effects equivalent to twicedaily dosing of MPH. This study tests the efficacy and duration of action, in natural and laboratory settings, of an extended-release MPH preparation designed to last 12 hours and therefore be equivalent to 3-times-daily dosing.
Pelham, W. E., Gnagy, E. M., Burrows-MacLean, L., Williams, A., Fabiano, G. A., Morrissey, S. M., Chronis, A. M., Forehand, G. L., Nguyen, C. A., Lock, T. M., Fiebelkorn, K., Coles, E. K., Panahon, C. J., Steiner, R. L., Meichenbaum, D. L., Onyango, A. N., & Morse, E. (2001). Once-a-day Concerta™ methylphenidate versus t.i.d. methylphenidate in laboratory and natural settings. Pediatrics,107(6), e105.
Publisher's Copyright and Source
Copyright © 2001 American Academy of Pediatrics. Article published by the American Academy of Pediatrics in Pediatrics, volume 107, issue number 6, page e105. Available online: http://doi.org/10.1542/peds.107.6.e105.