Title

Once-a-Day Concerta Methylphenidate versus t.i.d. Methylphenidate in Laboratory and Natual Settings

Document Type

Article

Publication Date

6-1-2001

Abstract

Methylphenidate (MPH), the most commonly prescribed drug for attention-deficit/hyperactivity disorder (ADHD), has a short half-life, which necessitates multiple daily doses. The need for multiple doses produces problems with medication administration during school and after-school hours, and therefore with compliance. Previous long-acting stimulants and preparations have shown effects equivalent to twicedaily dosing of MPH. This study tests the efficacy and duration of action, in natural and laboratory settings, of an extended-release MPH preparation designed to last 12 hours and therefore be equivalent to 3-times-daily dosing.

Publication Title

Pediatrics

DOI

10.1542/peds.107.6.e105