Event Title

Steatosis Induced by a High Fat Diet in Male Mice Livers

Location

CSU Ballroom

Start Date

16-4-2013 10:00 AM

End Date

16-4-2013 12:00 PM

Student's Major

Biological Sciences

Student's College

Science, Engineering and Technology

Mentor's Name

Steven Mercurio

Mentor's Department

Automotive and Manufacturing Engineering Technology

Mentor's College

Science, Engineering and Technology

Second Mentor's Name

Courtney Kupser

Second Mentor's Department

Biological Sciences

Second Mentor's College

Science, Engineering and Technology

Description

It is well known that chronic alcohol use can reduce the function of the liver in ways of scarring and reducing its ability to rid itself of lipids- leading to a fatty liver also known as the condition steatosis. It is less know that a high fat diet can cause the same effects. With the prevalence of high fat diets with availability of fast food and the rise in obesity the effects of a fatty liver have become relevant. To display this two groups of male mice were compared in a sub-acute study, one with a normal diet of 4% fat, and the other with a high fat diet of 11%. Densities of the liver, the ratio of mass of liver to overall body mass, color or visual lipid content were compared. Although the livers of the normal diet had a high variation of different colors marbling was seen only in the high fat livers supporting the hypothesis. The ratios of comparing the overall liver mass and body mass show have shown that the livers in the high fat diet are actually smaller than that compared to those of the normal diet but its densities had a lower p-value showing a high significance in difference. These two considerations of a smaller, denser liver could be due to hyperplasia and, if done in a chronic study, may show cancer.

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Apr 16th, 10:00 AM Apr 16th, 12:00 PM

Steatosis Induced by a High Fat Diet in Male Mice Livers

CSU Ballroom

It is well known that chronic alcohol use can reduce the function of the liver in ways of scarring and reducing its ability to rid itself of lipids- leading to a fatty liver also known as the condition steatosis. It is less know that a high fat diet can cause the same effects. With the prevalence of high fat diets with availability of fast food and the rise in obesity the effects of a fatty liver have become relevant. To display this two groups of male mice were compared in a sub-acute study, one with a normal diet of 4% fat, and the other with a high fat diet of 11%. Densities of the liver, the ratio of mass of liver to overall body mass, color or visual lipid content were compared. Although the livers of the normal diet had a high variation of different colors marbling was seen only in the high fat livers supporting the hypothesis. The ratios of comparing the overall liver mass and body mass show have shown that the livers in the high fat diet are actually smaller than that compared to those of the normal diet but its densities had a lower p-value showing a high significance in difference. These two considerations of a smaller, denser liver could be due to hyperplasia and, if done in a chronic study, may show cancer.

Recommended Citation

Yates Swedberg, Rachael. "Steatosis Induced by a High Fat Diet in Male Mice Livers." Undergraduate Research Symposium, Mankato, MN, April 16, 2013.
http://cornerstone.lib.mnsu.edu/urs/2013/poster-session-A/12