Event Title

Biocompatibility of Hydroxyapatite and Stainless Steel Alloys

Location

CSU Ballroom

Start Date

18-4-2016 10:00 AM

End Date

18-4-2016 11:30 AM

Student's Major

Biological Sciences

Student's College

Science, Engineering and Technology

Mentor's Name

Michael Bentley

Mentor's Department

Biological Sciences

Mentor's College

Science, Engineering and Technology

Second Mentor's Name

Kuldeep Agarwal

Second Mentor's Department

Automotive and Manufacturing Engineering Technology

Second Mentor's College

Science, Engineering and Technology

Description

The biomaterial used in medical implantable devices must sufficiently integrate within biological tissue and be biocompatible. One such metal is stainless steel. Hydroxyapatite (HA), a major and essential component of normal bone and teeth, is often used for coating metal implants to initiate infiltration. In the present study, our focus is on the biocompatibility of a mixture alloy of stainless steel and hydroxyapatite, fabricated by using a three-dimensional printer. To test the biocompatibility of the fabricated metal implant in vivo, one millimeter-sized metal pieces of high and low HA ratio mixture alloys were inserted on rat skulls through a small incision on the back made using a sterilized implantation surgery. After one month, the metal pieces were removed and observed under scanning electron microscopy to determine the degree of infiltrated bone and connective tissue. The surrounding connective tissues were also examined for inflammation and other tissue damages. The result showed that, the metal alloys were encapsulated by dense connective tissue continuous with dermis and periosteum without having any signs of inflammation or rejection. Furthermore, connective tissue infiltrated into spaces within alloy, between and around the spheres of stainless steel, to form a dense matrix of cellular and fibrous material throughout the implant. Our findings will help improve medical device alloys for hip, femur and other implants.

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Apr 18th, 10:00 AM Apr 18th, 11:30 AM

Biocompatibility of Hydroxyapatite and Stainless Steel Alloys

CSU Ballroom

The biomaterial used in medical implantable devices must sufficiently integrate within biological tissue and be biocompatible. One such metal is stainless steel. Hydroxyapatite (HA), a major and essential component of normal bone and teeth, is often used for coating metal implants to initiate infiltration. In the present study, our focus is on the biocompatibility of a mixture alloy of stainless steel and hydroxyapatite, fabricated by using a three-dimensional printer. To test the biocompatibility of the fabricated metal implant in vivo, one millimeter-sized metal pieces of high and low HA ratio mixture alloys were inserted on rat skulls through a small incision on the back made using a sterilized implantation surgery. After one month, the metal pieces were removed and observed under scanning electron microscopy to determine the degree of infiltrated bone and connective tissue. The surrounding connective tissues were also examined for inflammation and other tissue damages. The result showed that, the metal alloys were encapsulated by dense connective tissue continuous with dermis and periosteum without having any signs of inflammation or rejection. Furthermore, connective tissue infiltrated into spaces within alloy, between and around the spheres of stainless steel, to form a dense matrix of cellular and fibrous material throughout the implant. Our findings will help improve medical device alloys for hip, femur and other implants.

Recommended Citation

Hasan, Mehedi and Clenten Ndonwie. "Biocompatibility of Hydroxyapatite and Stainless Steel Alloys." Undergraduate Research Symposium, Mankato, MN, April 18, 2016.
http://cornerstone.lib.mnsu.edu/urs/2016/poster-session-A/27