Protein-Induced Calciuria in Diabetic Rats
To test a proposal that the hypercalciuria induced by excess dietary protein is due to stimulation of insulin secretion, the effects on urinary calcium of feeding a 15% protein versus a 35% protein diet to alloxandiabetic adult rats were compared. Although diabetes was associated with an increase in urinary calcium, a further increase in calcium, as well as sulfate, excretion was induced by feeding the high protein diet. The results support the conclusion reached in an earlier study that the hypercalciuria of chronic high protein feeding is due mainly to an increase in endogenous acid production arising from the oxidation of excess dietary sulfur amino acids.
Chemistry and Geology
Whiting, S.J., Draper, H.H., & Hadley, M. (1981). Nutrition Research, 1(6), 581-587. https://doi.org/10.1016/S0271-5317(81)80088-7
Publisher's Copyright and Source
Copyright © 1982 Elsevier, Inc.