[11C]raclopride Imaging of Dopamine Release in Rhesus Monkeys
For a variety of purposes we have begun implementation of a PET method for studying dopamine release. We used the dopamine D2-type receptor antagonist [11C]raclopride to study dopamine function in the rhesus monkey brain in response to an amphetamine challenge. [11C]raclopride is susceptible to competition from endogenous dopamine, whereby dopamine released into extracellular space reduces the number of binding sites available for the tracer.
Physics and Astronomy
Journal of Cerebral Blood Flow & Metabolism
A.K. Converse, T.E. Barnhart, C.B. Dallas, S. Jivan, J.A. Larson, T.R. Oakes, A.D. Roberts, T.J. Ruth, N.T. Vandehey, and M.L. Schneider. (2005). [11C]raclopride Imaging of Dopamine Release in Rhesus Monkeys. Journal of Cerebral Blood Flow & Metabolism, 25(S1), S647.
Publisher's Copyright and Source
Copyright © 2005 International Society for Cerebral Blood Flow & Metabolism. Abstract published by Nature Publishing Group in Journal of Cerebral Blood Flow & Metabolism, volume 25, supplement 1, 2005, page S647. Available online on August 30, 2005: https://doi.org/10.1038/sj.jcbfm.9591524.0647