Production of 17F, 15O and Other Radioisotopes for PET using a 3 MV Electrostatic Tandem Accelerator
Physics and Astronomy
Target systems for the production of positron emitting radioisotopes used for medical research with positron emission tomography (PET) are under development for a 3 MV electrostatic tandem accelerator (NEC 9SDH-2). This machine is intended primarily for the continuous production of short lived tracers labeled with 15O (t1/2=122 s) or 17F (t1/2=65 s) for determining regional cerebral blood flow in humans. Simple gas, liquid, and solid target systems are presented for the production of [15O]H2O (yield at saturation 13 mCi/μA), [17F]F2 (22 mCi/μA), [17F] fluoride (aq.) (12 mCi/μA), [18F] fluoride (aq.) (21 mCi/μA), [13N] in graphite (25 mCi/μA), and [11C]CO2 (2.3 mCi/μA). Current limitations on single window targets for each production are discussed.
Paper presented at the 15th International Conference on the Application of Accelerators in Research and Industry, November 4-7, 1998 in Denton, TX.
AIP Conference Proceeding
A.D. Roberts, R.J. Davidson, and R.J. Nickles. Production of 17F, 15O and Other Radioisotopes for PET using a 3 MV Electrostatic Tandem Accelerator. (1999). AIP Conference Proceedings, 475, 1006.
Publisher's Copyright and Source
Copyright © 1999 American Institute of Physics. Conference proceeding published by the American Institute of Physics in AIP Conference Proceedings, volume 475, 1999, page 1006. Available online: http://dx.doi.org/10.1063/1.59303.