Effect of Axial Resolution on PET Image Data: 2D vs. 3D
Physics and Astronomy
The authors compared 12 pairs of cerebral [18F]-fluorodeoxyglucose (FDG) 2D/3D image sets from a GE/Advance PET scanner, incorporating the actual corrections used on human subjects. Previously published values for spatial axial resolution in 2D  and 3D  modes were used to model the differential axial smoothing at each image voxel. This model was then applied to the 2D FDG images as well as to 2D spherical hot-spot phantom images; the resulting smoothed data indicate the published difference in axial resolution between 2D and 3D modes can account for 30-40% of the differences between these image sets. A phantom containing spherical hot- and cool-spots in a warm background was scanned for a variety of time-frame durations (30, 15, 5, 1 min) to mimic a typical human cerebral FDG PET scan. Only for the 1-minute frame (total counts 2D:6M, 3D:30M) is there an advantage to using 3D mode; for the longer frames which are more typical of a human FDG protocol, the reliability for extracting regions-of-interest is the same for either mode while 2D mode shows better quantitative accuracy.
1999 IEEE Nuclear Science Symposium Conference Record
T.R. Oakes, J.E. Holden, R.W. Pyzalski, A.D. Roberts, W.D. Brown, R.J. Nickles, and R.J. Davidson. (1999). Effect of Axial Resolution on PET Image Data: 2D vs. 3D. 1999 IEEE Nuclear Science Symposium Conference Record, volume 3, 1176-1181.
Publisher's Copyright and Source
Copyright © 1999 IEEE. Abstract published in 1999 IEEE Nuclear Science Symposium Conference Record, volume 3, October 1999, pages 1176-1181. Available online: http://doi.org/10.1109/NSSMIC.1999.842769.