Title

Improving the Yield of 2-[18F] Fluoro-2-Deoxyglucose Using a Microwave Cavity

Document Type

Article

Publication Date

7-1996

Department

Physics and Astronomy

Abstract

We have investigated the use of a microwave cavity (Labwell AB, Sweden) to improve the radiochemical yield of 2-[18F]fluoro-2-deoxyglucose (2-[18F]FDG). After characterizing the heating properties of the cavity, three steps of the Hamacher 2-[18F]FDG synthesis which require heating—azeotropic distillation of the target water, nucleophilic substitution, and hydrolysis of the product—were investigated separately. The average radiochemical yield of 2-[18F]FDG for the microwave synthesis, using the phase transfer reagent tetrabutylammonium bicarbonate, was 62 ± 4% (72 ± 5%, decay corrected, synthesis time = 31 min).

Publication Title

Nuclear Medicine and Biology

DOI

10.1016/0969-8051(96)00055-8