Improving the Yield of 2-[18F] Fluoro-2-Deoxyglucose Using a Microwave Cavity
Physics and Astronomy
We have investigated the use of a microwave cavity (Labwell AB, Sweden) to improve the radiochemical yield of 2-[18F]fluoro-2-deoxyglucose (2-[18F]FDG). After characterizing the heating properties of the cavity, three steps of the Hamacher 2-[18F]FDG synthesis which require heating—azeotropic distillation of the target water, nucleophilic substitution, and hydrolysis of the product—were investigated separately. The average radiochemical yield of 2-[18F]FDG for the microwave synthesis, using the phase transfer reagent tetrabutylammonium bicarbonate, was 62 ± 4% (72 ± 5%, decay corrected, synthesis time = 31 min).
Nuclear Medicine and Biology
M.D. Taylor, A.D. Roberts, and R.J. Nickles. (1996). Improving the Yield of 2-[18F] Fluoro-2-Deoxyglucose Using a Microwave Cavity. Nuclear Medicine and Biology, 23(5), 605-609.
Publisher's Copyright and Source
Copyright © 1996 Elsevier. Article published by Elsevier in Nuclear Medicine and Biology, volume 23, issue number 5, July 1996, pages 605-609. Available online on December 9, 1999: http://doi.org/10.1016/0969-8051(96)00055-8.