Improving the Yield of 2-[18F] Fluoro-2-Deoxyglucose Using a Microwave Cavity

Authors

M. D. Taylor, University of Wisconsin - Madison
Andrew D. Roberts, Minnesota State University - MankatoFollow
Robert J. Nickles, University of Wisconsin - Madison

Document Type

Article

Publication Date

7-1996

Abstract

We have investigated the use of a microwave cavity (Labwell AB, Sweden) to improve the radiochemical yield of 2-[¹⁸F]fluoro-2-deoxyglucose (2-[¹⁸F]FDG). After characterizing the heating properties of the cavity, three steps of the Hamacher 2-[¹⁸F]FDG synthesis which require heating—azeotropic distillation of the target water, nucleophilic substitution, and hydrolysis of the product—were investigated separately. The average radiochemical yield of 2-[¹⁸F]FDG for the microwave synthesis, using the phase transfer reagent tetrabutylammonium bicarbonate, was 62 ± 4% (72 ± 5%, decay corrected, synthesis time = 31 min).

Department

Physics and Astronomy

Publication Title

Nuclear Medicine and Biology

Recommended Citation

M.D. Taylor, A.D. Roberts, and R.J. Nickles. (1996). Improving the Yield of 2-[18F] Fluoro-2-Deoxyglucose Using a Microwave Cavity. Nuclear Medicine and Biology, 23(5), 605-609.

DOI

10.1016/0969-8051(96)00055-8

Link to Publisher Version (DOI)

https://doi.org/10.1016/0969-8051(96)00055-8

Publisher's Copyright and Source

Copyright © 1996 Elsevier. Article published by Elsevier in Nuclear Medicine and Biology, volume 23, issue number 5, July 1996, pages 605-609. Available online on December 9, 1999: https://doi.org/10.1016/0969-8051(96)00055-8