Isolation of a Guanine-Malondialdehyde Adduct from Rat and Human Urine
Document Type
Article
Publication Date
2-1990
Abstract
A 1∶1 adduct of guanine with malondialdehyde (MDA) was isolated from rat and human urine. This compound was shown to be identical to a synthetic adduct prepared according to the procedure of Setoet al. (Bull. Chem. Soc. Jpn. 58, 3431–3435, 1985). The UV, NMR and other characteristics of the compound were consistent with the tricyclic pyrimidinopurine structure proposed by these investigators. Its endogenous origin is indicated by its presence in the urine of rats fed an MDA-free diet, and by the observation that its excretion increased following iron or carbon tetrachloride administration. It may serve as a marker for nucleic acid modification caused by lipid peroxidationin vivo.
Department
Chemistry and Geology
Print ISSN
0024-4201
Publication Title
Lipids
Recommended Citation
Hadley, M., Draper, H.H. Isolation of a guanine-malondialdehyde adduct from rat and human urine. Lipids 25, 82–85 (1990). https://doi.org/10.1007/BF02562209
DOI
10.1007/BF02562209
Link to Publisher Version (DOI)
Publisher's Copyright and Source
Copyright © 1990 American Oil Chemists' Society (AOCS)
