Title

Isolation of a Guanine-Malondialdehyde Adduct from Rat and Human Urine

Document Type

Article

Publication Date

2-1990

Abstract

A 1∶1 adduct of guanine with malondialdehyde (MDA) was isolated from rat and human urine. This compound was shown to be identical to a synthetic adduct prepared according to the procedure of Setoet al. (Bull. Chem. Soc. Jpn. 58, 3431–3435, 1985). The UV, NMR and other characteristics of the compound were consistent with the tricyclic pyrimidinopurine structure proposed by these investigators. Its endogenous origin is indicated by its presence in the urine of rats fed an MDA-free diet, and by the observation that its excretion increased following iron or carbon tetrachloride administration. It may serve as a marker for nucleic acid modification caused by lipid peroxidationin vivo.

Department

Chemistry and Geology

Print ISSN

0024-4201

Publication Title

Lipids

DOI

10.1007/BF02562209

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