Protein-Induced Calciuria in Diabetic Rats

Document Type

Article

Publication Date

1981

Abstract

To test a proposal that the hypercalciuria induced by excess dietary protein is due to stimulation of insulin secretion, the effects on urinary calcium of feeding a 15% protein versus a 35% protein diet to alloxandiabetic adult rats were compared. Although diabetes was associated with an increase in urinary calcium, a further increase in calcium, as well as sulfate, excretion was induced by feeding the high protein diet. The results support the conclusion reached in an earlier study that the hypercalciuria of chronic high protein feeding is due mainly to an increase in endogenous acid production arising from the oxidation of excess dietary sulfur amino acids.

Department

Chemistry and Geology

Print ISSN

0271-5317

Publication Title

Nutrition Research

DOI

10.1016/S0271-5317(81)80088-7

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