Affects of Blood Pressure of the Offspring of SHR Subjected to Aldosterone Infusion During Gestation
Location
CSU
Student's Major
Biological Sciences
Student's College
Science, Engineering and Technology
Mentor's Name
Penny Knoblich
Mentor's Department
Biological Sciences
Mentor's College
Science, Engineering and Technology
Description
The spontaneously hypertensive rat (SHR) is a model for the study of hypertension. Research has shown that restricting sodium intake of the mother during pregnancy may reduce severity of hypertension in the offspring. Low sodium diets have been shown to markedly increase the hormone, aldosterone. Thus the rise in aldosterone may be responsible for the reduced blood pressure in the offspring. The purpose of this study is to examine the affect on the offspring of SHR exposed to elevated plasma aldosterone without sodium restriction during gestation. Twelve female SHR will be mated to SHR males and, once pregnant, assigned randomly to one of two groups; Control - Pregnant SHR infused with vehicle; Aldosterone-treated - Pregnant SHR infused with aldosterone. During pregnancy and the early postpartum period, an osmotic minipump will be used to increase plasma aldosterone to the extent that occurs with sodium restriction. Systolic blood pressure, measured by the tail-cuff method, will be used on the pups at five weeks of age and continue biweekly until pups are 21 weeks of age. The development of hypertension will then be compared between groups of offspring.
Affects of Blood Pressure of the Offspring of SHR Subjected to Aldosterone Infusion During Gestation
CSU
The spontaneously hypertensive rat (SHR) is a model for the study of hypertension. Research has shown that restricting sodium intake of the mother during pregnancy may reduce severity of hypertension in the offspring. Low sodium diets have been shown to markedly increase the hormone, aldosterone. Thus the rise in aldosterone may be responsible for the reduced blood pressure in the offspring. The purpose of this study is to examine the affect on the offspring of SHR exposed to elevated plasma aldosterone without sodium restriction during gestation. Twelve female SHR will be mated to SHR males and, once pregnant, assigned randomly to one of two groups; Control - Pregnant SHR infused with vehicle; Aldosterone-treated - Pregnant SHR infused with aldosterone. During pregnancy and the early postpartum period, an osmotic minipump will be used to increase plasma aldosterone to the extent that occurs with sodium restriction. Systolic blood pressure, measured by the tail-cuff method, will be used on the pups at five weeks of age and continue biweekly until pups are 21 weeks of age. The development of hypertension will then be compared between groups of offspring.
