Affects of Regular Voluntary Exercise of Pregnant Spontaneously Hypertensive Rats (SHR) on the Development of Hypertension in the Subsequent Offspring

Location

CSU

Student's Major

Biological Sciences

Student's College

Science, Engineering and Technology

Mentor's Name

Penny Knoblich

Mentor's Department

Biological Sciences

Mentor's College

Science, Engineering and Technology

Second Mentor's Name

Jeff Gilbert

Second Mentor's Department

Biological Sciences

Second Mentor's College

Science, Engineering and Technology

Description

No studies have examined the affect of maternal exercise on the degree of hypertension development in the offspring. The spontaneously hypertensive rat (SHR) is a model for the study of hypertension. This study will investigate the affects of regular, voluntary exercise of pregnant SHR on the development of hypertension in the subsequent offspring. All exercise will occur on an exercise wheel connected to a device that logs distance run. An average distance will be determined per study group for each week of the study. Systolic blood pressure of the offspring will be measure biweekly from five to 21 weeks of age. Twenty-four females will be assigned to one of three groups; Group 1 (sedentary) - no exercise before or during pregnancy; Group 2 (exercised) - exercise wheels will be placed in the cages immediately after confirmation of breeding and will be removed after the birth of the pups; Group 3 (pretrained) - exercise wheels will be placed in the cages at least three weeks prior to breeding and will be removed after the birth of the pups.

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Affects of Regular Voluntary Exercise of Pregnant Spontaneously Hypertensive Rats (SHR) on the Development of Hypertension in the Subsequent Offspring

CSU

No studies have examined the affect of maternal exercise on the degree of hypertension development in the offspring. The spontaneously hypertensive rat (SHR) is a model for the study of hypertension. This study will investigate the affects of regular, voluntary exercise of pregnant SHR on the development of hypertension in the subsequent offspring. All exercise will occur on an exercise wheel connected to a device that logs distance run. An average distance will be determined per study group for each week of the study. Systolic blood pressure of the offspring will be measure biweekly from five to 21 weeks of age. Twenty-four females will be assigned to one of three groups; Group 1 (sedentary) - no exercise before or during pregnancy; Group 2 (exercised) - exercise wheels will be placed in the cages immediately after confirmation of breeding and will be removed after the birth of the pups; Group 3 (pretrained) - exercise wheels will be placed in the cages at least three weeks prior to breeding and will be removed after the birth of the pups.