Affects of Regular Voluntary Exercise of Pregnant Spontaneously Hypertensive Rats (SHR) on the Development of Hypertension in the Subsequent Offspring
Location
CSU
Student's Major
Biological Sciences
Student's College
Science, Engineering and Technology
Mentor's Name
Penny Knoblich
Mentor's Department
Biological Sciences
Mentor's College
Science, Engineering and Technology
Second Mentor's Name
Jeff Gilbert
Second Mentor's Department
Biological Sciences
Second Mentor's College
Science, Engineering and Technology
Description
No studies have examined the affect of maternal exercise on the degree of hypertension development in the offspring. The spontaneously hypertensive rat (SHR) is a model for the study of hypertension. This study will investigate the affects of regular, voluntary exercise of pregnant SHR on the development of hypertension in the subsequent offspring. All exercise will occur on an exercise wheel connected to a device that logs distance run. An average distance will be determined per study group for each week of the study. Systolic blood pressure of the offspring will be measure biweekly from five to 21 weeks of age. Twenty-four females will be assigned to one of three groups; Group 1 (sedentary) - no exercise before or during pregnancy; Group 2 (exercised) - exercise wheels will be placed in the cages immediately after confirmation of breeding and will be removed after the birth of the pups; Group 3 (pretrained) - exercise wheels will be placed in the cages at least three weeks prior to breeding and will be removed after the birth of the pups.
Affects of Regular Voluntary Exercise of Pregnant Spontaneously Hypertensive Rats (SHR) on the Development of Hypertension in the Subsequent Offspring
CSU
No studies have examined the affect of maternal exercise on the degree of hypertension development in the offspring. The spontaneously hypertensive rat (SHR) is a model for the study of hypertension. This study will investigate the affects of regular, voluntary exercise of pregnant SHR on the development of hypertension in the subsequent offspring. All exercise will occur on an exercise wheel connected to a device that logs distance run. An average distance will be determined per study group for each week of the study. Systolic blood pressure of the offspring will be measure biweekly from five to 21 weeks of age. Twenty-four females will be assigned to one of three groups; Group 1 (sedentary) - no exercise before or during pregnancy; Group 2 (exercised) - exercise wheels will be placed in the cages immediately after confirmation of breeding and will be removed after the birth of the pups; Group 3 (pretrained) - exercise wheels will be placed in the cages at least three weeks prior to breeding and will be removed after the birth of the pups.
