Attempting the Impossible: The Quantification of Pain
Location
CSU 253/4/5
Start Date
24-4-2007 10:30 AM
End Date
24-4-2007 12:30 PM
Student's Major
Biological Sciences
Student's College
Science, Engineering and Technology
Mentor's Name
Dawn Albertson
Mentor's Department
Psychology
Mentor's College
Social and Behavioral Sciences
Description
In the practice of medicine, many doctors and nurses rely on the Wong-Baker Face Pain Rating Scale to determine a patient's level of pain. Consequently, this pain scale is subjective in that it relies only on a patient's self report. Therefore, there is a need for the development of an objective measurement of pain. This exploratory study attempted to quantify ProstaglandinE2 (PGE2) in a rat model, in response to pain. PGB2 is secreted upon cellular injury and therefore acts as a messenger of pain. Uric acid crystals were injected into the intracapsular space of a randomly selected hind limb to induce joint pain. An Enzyme- • Linked ImmunoSorbent Assay kit (ELIS A) was used to chart the time course of alterations in PGE2 levels. In addition, an analysis of the rat's behavior in response to pain was obtained and correlated with the alterations of PGE2. This study represents the first in a series that will be combined to create an objective pain scale. The results from the study will be presented.
Attempting the Impossible: The Quantification of Pain
CSU 253/4/5
In the practice of medicine, many doctors and nurses rely on the Wong-Baker Face Pain Rating Scale to determine a patient's level of pain. Consequently, this pain scale is subjective in that it relies only on a patient's self report. Therefore, there is a need for the development of an objective measurement of pain. This exploratory study attempted to quantify ProstaglandinE2 (PGE2) in a rat model, in response to pain. PGB2 is secreted upon cellular injury and therefore acts as a messenger of pain. Uric acid crystals were injected into the intracapsular space of a randomly selected hind limb to induce joint pain. An Enzyme- • Linked ImmunoSorbent Assay kit (ELIS A) was used to chart the time course of alterations in PGE2 levels. In addition, an analysis of the rat's behavior in response to pain was obtained and correlated with the alterations of PGE2. This study represents the first in a series that will be combined to create an objective pain scale. The results from the study will be presented.
Recommended Citation
Pyka, Mary. "Attempting the Impossible: The Quantification of Pain." Undergraduate Research Symposium, Mankato, MN, April 24, 2007.
https://cornerstone.lib.mnsu.edu/urs/2007/poster-session-C/6
