Event Title

Analysis of Potential Chemical Reactivity's Between Selected O-T-C and Commonly Prescribed Drugs

Presenter Information

Lindsey Faulks, Minnesota State University, Mankato

Location

CSU Ballroom

Start Date

21-4-2008 1:00 PM

End Date

21-4-2008 3:00 PM

Student's Major

Chemistry and Geology

Student's College

Science, Engineering and Technology

Mentor's Name

Danae Quirk Dorr

Mentor's Department

Chemistry and Geology

Mentor's College

Science, Engineering and Technology

Description

Potential drug-drug reactions between over-the-counter (OTC) medications and commonly prescribed drugs were the focus of this proposal. Various drugs were classified based upon their chemical structures and reactive sites. These drugs were organized into a table format illustrating the different functional groups present in the drugs' chemical structures. Out of sixty-eight drugs analyzed, six were chosen as the primary focus of this experiment. The six drugs include atenolol, captopril, pseudoephedrine, amantadine, metformin, and acyclovir. The goal of this proposal was to correctly predict which drugs would react when taken concurrently. The six selected drugs were reacted under acidic conditions to represent the stomach environment. The reaction solutions were analyzed appropriately by HPLC and LCMS.