Vasculature Regeneration Following Partial Hepatectomy in the Rat
Location
CSU Ballroom
Start Date
21-4-2008 1:00 PM
End Date
21-4-2008 3:00 PM
Student's Major
Biological Sciences
Student's College
Science, Engineering and Technology
Mentor's Name
Michael Bentley
Mentor's Department
Biological Sciences
Mentor's College
Science, Engineering and Technology
Description
It is well known that when a portion of liver tissue is removed, the remaining tissue will undergo regeneration. Although much is known about the regeneration process, very little is known about the regrowth of the vasculature in the liver. Partial hepatectomies were performed on rats to further analyze the regrowth of the vasculature. Twelve adult rats were used for this study. Six rats were used for sham surgeries and the other six were used for the partial hepatectomy. Two weeks after the surgeries, each rat was reopened and the vasculature of its liver was infused with plastic. The resulting casts of the vasculature were studied microscopically. The results show that, by two weeks after the hepatectomy, the remaining tissue of the experimental livers increases in size and has a mass comparable to the control. The results further indicate that vascular regrowth occurs in remaining lobes and not at the site of resection. These findings indicate that vascular regrowth is an integral part of liver regeneration and that new tissue that forms at the site of resection interferes with the regeneration process.
Vasculature Regeneration Following Partial Hepatectomy in the Rat
CSU Ballroom
It is well known that when a portion of liver tissue is removed, the remaining tissue will undergo regeneration. Although much is known about the regeneration process, very little is known about the regrowth of the vasculature in the liver. Partial hepatectomies were performed on rats to further analyze the regrowth of the vasculature. Twelve adult rats were used for this study. Six rats were used for sham surgeries and the other six were used for the partial hepatectomy. Two weeks after the surgeries, each rat was reopened and the vasculature of its liver was infused with plastic. The resulting casts of the vasculature were studied microscopically. The results show that, by two weeks after the hepatectomy, the remaining tissue of the experimental livers increases in size and has a mass comparable to the control. The results further indicate that vascular regrowth occurs in remaining lobes and not at the site of resection. These findings indicate that vascular regrowth is an integral part of liver regeneration and that new tissue that forms at the site of resection interferes with the regeneration process.
Recommended Citation
Frank, Brittany and Sarah Karalus. "Vasculature Regeneration Following Partial Hepatectomy in the Rat." Undergraduate Research Symposium, Mankato, MN, April 21, 2008.
https://cornerstone.lib.mnsu.edu/urs/2008/poster-session-B/9
