Investigating the Role that Compounds in Vanilla and Cinnamon Play in Preventing Cancer

Location

CSU Ballroom

Start Date

28-4-2009 10:00 AM

End Date

28-4-2009 12:00 PM

Student's Major

Chemistry and Geology

Student's College

Science, Engineering and Technology

Mentor's Name

Danaè Quirk Dorr

Mentor's Department

Chemistry and Geology

Mentor's College

Science, Engineering and Technology

Description

Vanillin (VAN) and Cinnamaldehyde (CIN) are food flavoring compounds. They are the main flavoring components fotmd in vanilla and cinnamon, respectively. It has been reported that these compounds demonstrate antimutagenic properties against .E. coli strains. In addition, it was also reported that in Salmonnella TA 104, VAN and CIN reduced mutation at the guanine-cytosine but not adenine-thymidine sites. Recently, it was reported that both VAN and CIN were antimutagenic in human colon cancer cell line HCTl 16. The mechanism for the antimutagenic effects of VAN and CIN remain unclear. To elucidate a better understanding of the antimutagenic mechanisms of these interesting compounds, this project focused on characterizing the products of reactions that occur when DNA, 2'-deoxyguanosine, and guanosine are treated with VAN and CIN. The products were analyzed by High Pressure Liquid Chromatography.

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Apr 28th, 10:00 AM Apr 28th, 12:00 PM

Investigating the Role that Compounds in Vanilla and Cinnamon Play in Preventing Cancer

CSU Ballroom

Vanillin (VAN) and Cinnamaldehyde (CIN) are food flavoring compounds. They are the main flavoring components fotmd in vanilla and cinnamon, respectively. It has been reported that these compounds demonstrate antimutagenic properties against .E. coli strains. In addition, it was also reported that in Salmonnella TA 104, VAN and CIN reduced mutation at the guanine-cytosine but not adenine-thymidine sites. Recently, it was reported that both VAN and CIN were antimutagenic in human colon cancer cell line HCTl 16. The mechanism for the antimutagenic effects of VAN and CIN remain unclear. To elucidate a better understanding of the antimutagenic mechanisms of these interesting compounds, this project focused on characterizing the products of reactions that occur when DNA, 2'-deoxyguanosine, and guanosine are treated with VAN and CIN. The products were analyzed by High Pressure Liquid Chromatography.

Recommended Citation

Nguyen, Vy T.. "Investigating the Role that Compounds in Vanilla and Cinnamon Play in Preventing Cancer." Undergraduate Research Symposium, Mankato, MN, April 28, 2009.
https://cornerstone.lib.mnsu.edu/urs/2009/poster-session-C/28