Investigating the Role that Compounds in Vanilla and Cinnamon Play in Preventing Cancer
Location
CSU Ballroom
Start Date
28-4-2009 10:00 AM
End Date
28-4-2009 12:00 PM
Student's Major
Chemistry and Geology
Student's College
Science, Engineering and Technology
Mentor's Name
Danaè Quirk Dorr
Mentor's Department
Chemistry and Geology
Mentor's College
Science, Engineering and Technology
Description
Vanillin (VAN) and Cinnamaldehyde (CIN) are food flavoring compounds. They are the main flavoring components fotmd in vanilla and cinnamon, respectively. It has been reported that these compounds demonstrate antimutagenic properties against .E. coli strains. In addition, it was also reported that in Salmonnella TA 104, VAN and CIN reduced mutation at the guanine-cytosine but not adenine-thymidine sites. Recently, it was reported that both VAN and CIN were antimutagenic in human colon cancer cell line HCTl 16. The mechanism for the antimutagenic effects of VAN and CIN remain unclear. To elucidate a better understanding of the antimutagenic mechanisms of these interesting compounds, this project focused on characterizing the products of reactions that occur when DNA, 2'-deoxyguanosine, and guanosine are treated with VAN and CIN. The products were analyzed by High Pressure Liquid Chromatography.
Investigating the Role that Compounds in Vanilla and Cinnamon Play in Preventing Cancer
CSU Ballroom
Vanillin (VAN) and Cinnamaldehyde (CIN) are food flavoring compounds. They are the main flavoring components fotmd in vanilla and cinnamon, respectively. It has been reported that these compounds demonstrate antimutagenic properties against .E. coli strains. In addition, it was also reported that in Salmonnella TA 104, VAN and CIN reduced mutation at the guanine-cytosine but not adenine-thymidine sites. Recently, it was reported that both VAN and CIN were antimutagenic in human colon cancer cell line HCTl 16. The mechanism for the antimutagenic effects of VAN and CIN remain unclear. To elucidate a better understanding of the antimutagenic mechanisms of these interesting compounds, this project focused on characterizing the products of reactions that occur when DNA, 2'-deoxyguanosine, and guanosine are treated with VAN and CIN. The products were analyzed by High Pressure Liquid Chromatography.
Recommended Citation
Nguyen, Vy T.. "Investigating the Role that Compounds in Vanilla and Cinnamon Play in Preventing Cancer." Undergraduate Research Symposium, Mankato, MN, April 28, 2009.
https://cornerstone.lib.mnsu.edu/urs/2009/poster-session-C/28
