Synthesis of a Novel Podophyllotoxin Derivative for Use as an Anti-Cancer Drug
Location
CSU Ballroom
Start Date
28-4-2009 10:00 AM
End Date
28-4-2009 12:00 PM
Student's Major
Chemistry and Geology
Student's College
Science, Engineering and Technology
Mentor's Name
Danae Quirk Dorr
Mentor's Department
Chemistry and Geology
Mentor's College
Science, Engineering and Technology
Description
Podophyllotoxin and its derivatives are well-studied and widely used in a broad range of therapeutic applications, most notably as anti-cancer drugs. It has been previously shown that derivatives of podophyllotoxin are often more potent and have mechanisms of action against cancer cells that differ from the parent compound. In order to potentially maximize the potency of a podophyllotoxin derivative, an additional compound with known anti-cancer properties was chosen to be added to the podophyllotoxin structure. Starting with 2,3-dimethoxybenzaldehyde, a multi-step total synthesis was conducted to yield a podophyllotoxin-like molecule. Intermediate structures were purified by flash chromatography and characterized by Nuclear Magnetic Resonance Spectroscopy (NMR).
Synthesis of a Novel Podophyllotoxin Derivative for Use as an Anti-Cancer Drug
CSU Ballroom
Podophyllotoxin and its derivatives are well-studied and widely used in a broad range of therapeutic applications, most notably as anti-cancer drugs. It has been previously shown that derivatives of podophyllotoxin are often more potent and have mechanisms of action against cancer cells that differ from the parent compound. In order to potentially maximize the potency of a podophyllotoxin derivative, an additional compound with known anti-cancer properties was chosen to be added to the podophyllotoxin structure. Starting with 2,3-dimethoxybenzaldehyde, a multi-step total synthesis was conducted to yield a podophyllotoxin-like molecule. Intermediate structures were purified by flash chromatography and characterized by Nuclear Magnetic Resonance Spectroscopy (NMR).
Recommended Citation
Wagner, Abigail K.. "Synthesis of a Novel Podophyllotoxin Derivative for Use as an Anti-Cancer Drug." Undergraduate Research Symposium, Mankato, MN, April 28, 2009.
https://cornerstone.lib.mnsu.edu/urs/2009/poster-session-C/30
