Synthesis of a Novel Podophyllotoxin Derivative for Use as an Anti-Cancer Drug

Location

CSU Ballroom

Start Date

28-4-2009 10:00 AM

End Date

28-4-2009 12:00 PM

Student's Major

Chemistry and Geology

Student's College

Science, Engineering and Technology

Mentor's Name

Danae Quirk Dorr

Mentor's Department

Chemistry and Geology

Mentor's College

Science, Engineering and Technology

Description

Podophyllotoxin and its derivatives are well-studied and widely used in a broad range of therapeutic applications, most notably as anti-cancer drugs. It has been previously shown that derivatives of podophyllotoxin are often more potent and have mechanisms of action against cancer cells that differ from the parent compound. In order to potentially maximize the potency of a podophyllotoxin derivative, an additional compound with known anti-cancer properties was chosen to be added to the podophyllotoxin structure. Starting with 2,3-dimethoxybenzaldehyde, a multi-step total synthesis was conducted to yield a podophyllotoxin-like molecule. Intermediate structures were purified by flash chromatography and characterized by Nuclear Magnetic Resonance Spectroscopy (NMR).

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Apr 28th, 10:00 AM Apr 28th, 12:00 PM

Synthesis of a Novel Podophyllotoxin Derivative for Use as an Anti-Cancer Drug

CSU Ballroom

Podophyllotoxin and its derivatives are well-studied and widely used in a broad range of therapeutic applications, most notably as anti-cancer drugs. It has been previously shown that derivatives of podophyllotoxin are often more potent and have mechanisms of action against cancer cells that differ from the parent compound. In order to potentially maximize the potency of a podophyllotoxin derivative, an additional compound with known anti-cancer properties was chosen to be added to the podophyllotoxin structure. Starting with 2,3-dimethoxybenzaldehyde, a multi-step total synthesis was conducted to yield a podophyllotoxin-like molecule. Intermediate structures were purified by flash chromatography and characterized by Nuclear Magnetic Resonance Spectroscopy (NMR).

Recommended Citation

Wagner, Abigail K.. "Synthesis of a Novel Podophyllotoxin Derivative for Use as an Anti-Cancer Drug." Undergraduate Research Symposium, Mankato, MN, April 28, 2009.
https://cornerstone.lib.mnsu.edu/urs/2009/poster-session-C/30