Investigation of the Effects of Cinnamaldehyde and Vanillin on 2'-Deoxyguanosine and 2'- Deoxyadenosine

Presenter Information

Katelyn Taylor, Minnesota State University, Mankato

Location

CSU 253/4/5

Start Date

4-4-2011 11:00 AM

End Date

4-4-2011 12:30 PM

Student's Major

Chemistry and Geology

Student's College

Science, Engineering and Technology

Mentor's Name

Danae Quirk Dorr

Mentor's Department

Chemistry and Geology

Mentor's College

Science, Engineering and Technology

Description

Cinnamaldehyde and vanillin are compounds which are present in the common food flavorings cinnamon and vanilla. Cinnamaldehyde and vanillin have been shown to induce the cell's ability to repair mutated DNA specifically at the sites where guanosine has been mutated. However, the precise reaction which cinnamaldehyde and vanillin undergo with guanosine and the mutation induced is poorly understood.

Previous research has shown that α,β-unsaturated aldehydes form exocyclic adducts with 2'-deoxyguanosine. The focus of this research was to synthesize possible exocyclic products of cinnamaldehyde and vanillin with 2'-deoxyguanosine and 2'-deoxyadenosine. The results of these synthetic reactions were compared with the results obtained when calf thymus DNA was independently treated with cinnamaldehyde and vanillin.