Further Investigating the Reactivity of Citral and Octanal toward DNA
Location
CSU Ballroom
Start Date
21-4-2014 10:00 AM
End Date
21-4-2014 11:30 AM
Student's Major
Chemistry and Geology
Student's College
Science, Engineering and Technology
Mentor's Name
Mary Hadley
Mentor's Email Address
mary.hadley@mnsu.edu
Mentor's Department
Chemistry and Geology
Mentor's College
Science, Engineering and Technology
Description
This year’s research is looking farther into interaction of the natural occurring aldehydes citral and octanal. These compounds are found naturally in fruits, grasses and are in perfumes and essential oils. Some of these foods are oranges and lemons, but citral is found in a high percentage in lemongrass oil. The research conducted last year found that citral and octanal were able to interact with 2’deoxyguanosine. Further research will be conducted to see if an adduct can be purified and characterized to understand the interaction of DNA and the two aldehydes. In the past, a number of aldehydes have been found to covalently bind to DNA for example acrolein and malondialdehyde. If citral and octanal are able to bond to the DNA, it could potentially be used for preventative measures in diseases because it could lead to repair of the strand of DNA that could have been damaged. By using this repair when aldehydes bond to the DNA it could be used to prevent many diseases that occur from the mutation of DNA such as cancer. Cancer is a growing issue across the globe and looking to discover different options for the preventative treatment versus the current treatment would be very beneficial for society because of the close to 7.6 million people who die of cancer annually.
Further Investigating the Reactivity of Citral and Octanal toward DNA
CSU Ballroom
This year’s research is looking farther into interaction of the natural occurring aldehydes citral and octanal. These compounds are found naturally in fruits, grasses and are in perfumes and essential oils. Some of these foods are oranges and lemons, but citral is found in a high percentage in lemongrass oil. The research conducted last year found that citral and octanal were able to interact with 2’deoxyguanosine. Further research will be conducted to see if an adduct can be purified and characterized to understand the interaction of DNA and the two aldehydes. In the past, a number of aldehydes have been found to covalently bind to DNA for example acrolein and malondialdehyde. If citral and octanal are able to bond to the DNA, it could potentially be used for preventative measures in diseases because it could lead to repair of the strand of DNA that could have been damaged. By using this repair when aldehydes bond to the DNA it could be used to prevent many diseases that occur from the mutation of DNA such as cancer. Cancer is a growing issue across the globe and looking to discover different options for the preventative treatment versus the current treatment would be very beneficial for society because of the close to 7.6 million people who die of cancer annually.
Recommended Citation
Leeder, Brittany. "Further Investigating the Reactivity of Citral and Octanal toward DNA." Undergraduate Research Symposium, Mankato, MN, April 21, 2014.
https://cornerstone.lib.mnsu.edu/urs/2014/poster_session_A/37
