Exploring Reactions Between Substituted-Aromatic Aldehydes and Guanosine

Presenter Information

Dahye Kim, Minnesota State University, Mankato

Location

CSU Ballroom

Start Date

11-4-2017 10:00 AM

End Date

11-4-2017 11:30 AM

Student's Major

Chemistry and Geology

Student's College

Science, Engineering and Technology

Mentor's Name

Danae Quirk Dorr

Mentor's Department

Chemistry and Geology

Mentor's College

Science, Engineering and Technology

Description

The reactivity of substituted-aromatic aldehydes with guanosine and arginine can help elucidate information about how these chemicals could react within our bodies. The aromatic aldehydes selected in this experiment include o-nitrobenzaldehyde, p-nitrobenzaldehyde, salicylaldehyde, and 5-nitrosalicylaldehyde. Reactivity of each aldehyde was explored through four different reactions: 1) aldehyde alone, 2) aldehyde with guanosine, 3) aldehyde with arginine and 4) aldehyde with guanosine and arginine. In total, sixteen separate reactions were conducted at 50C. d6-Dimethyl sulfoxide was used as the solvent in each reaction. Reaction mixtures were analyzed by proton nuclear magnetic resonance (H1-NMR) and high performance liquid chromatography (HPLC).