Connective Tissue Infiltration into Three-Dimensional Sintered Cobalt Chrome Alloy
Location
CSU Ballroom
Start Date
2-4-2019 10:00 AM
End Date
2-4-2019 11:30 AM
Student's Major
Biological Sciences
Student's College
Science, Engineering and Technology
Mentor's Name
Michael Bentley
Mentor's Department
Biological Sciences
Mentor's College
Science, Engineering and Technology
Description
The biomaterial used in medical implantable devices must sufficiently integrate within the biological system and be compatible with surrounding tissue. In this study, cobalt chrome (CC) will be utilized, offering high biocompatibility while minimizing immune reactivity. CC will be used in conjunction with Hydroxyapatite (HA), a bioactive material that is an essential component of normal bone and teeth. HA's bioactivity leads to high biodegradation when implanted alone, which can result in clinical implant failure. In our study, we will test the biocompatibility of a mixture alloy, fabricated using a three-dimensional printer. To test the biocompatibility of the fabricated metal implant in-vivo, one-by-two-by-four millimeter metal pieces (20% HA, 80% CC) mixture alloys will be inserted on rat skulls through a small incision made via sterilized surgery. After five weeks, the implants and surrounding tissue will be removed and observed using scanning electron microscopy. The surrounding connective tissues will be examined for inflammation and other signs of tissue damage or rejection. We hypothesize that the metal alloys will be encapsulated by dense connective tissue continuous with the periosteum and will show no signs of inflammation or rejection. Furthermore, connective tissue will infiltrate into spaces within the alloy, between and around the alloy spheres to form a dense matrix of cellular and fibrous material throughout the implant. These findings will help contribute to the science of medical implantation and tissue rejection and improve our understanding of medical device alloys used for hip, femur and other implants.
Connective Tissue Infiltration into Three-Dimensional Sintered Cobalt Chrome Alloy
CSU Ballroom
The biomaterial used in medical implantable devices must sufficiently integrate within the biological system and be compatible with surrounding tissue. In this study, cobalt chrome (CC) will be utilized, offering high biocompatibility while minimizing immune reactivity. CC will be used in conjunction with Hydroxyapatite (HA), a bioactive material that is an essential component of normal bone and teeth. HA's bioactivity leads to high biodegradation when implanted alone, which can result in clinical implant failure. In our study, we will test the biocompatibility of a mixture alloy, fabricated using a three-dimensional printer. To test the biocompatibility of the fabricated metal implant in-vivo, one-by-two-by-four millimeter metal pieces (20% HA, 80% CC) mixture alloys will be inserted on rat skulls through a small incision made via sterilized surgery. After five weeks, the implants and surrounding tissue will be removed and observed using scanning electron microscopy. The surrounding connective tissues will be examined for inflammation and other signs of tissue damage or rejection. We hypothesize that the metal alloys will be encapsulated by dense connective tissue continuous with the periosteum and will show no signs of inflammation or rejection. Furthermore, connective tissue will infiltrate into spaces within the alloy, between and around the alloy spheres to form a dense matrix of cellular and fibrous material throughout the implant. These findings will help contribute to the science of medical implantation and tissue rejection and improve our understanding of medical device alloys used for hip, femur and other implants.
Recommended Citation
Haus, Bethany and Eryn Zuiker. "Connective Tissue Infiltration into Three-Dimensional Sintered Cobalt Chrome Alloy." Undergraduate Research Symposium, Mankato, MN, April 2, 2019.
https://cornerstone.lib.mnsu.edu/urs/2019/poster-session-A/4
