Myosin Oxidation and Effects on Magnesium and Actin Binding: Actomyosin

Start Date

15-4-2021 3:30 PM

End Date

15-4-2021 4:30 PM

Student's Major

Biochemistry

Student's College

Science, Engineering and Technology

Mentor's Name

Rebecca Moen

Mentor's Department

Biochemistry, Chemistry and Geology

Mentor's College

Science, Engineering and Technology

Description

Muscles are responsible for producing force throughout the human body. Muscle tissue is divided into three general types: skeletal, cardiac and smooth muscle. Our muscles are prime targets of oxidative stress as they must respond effectively to influences such as exercise, hormonal changes, development and aging (1). Repetitive muscle contractions lead to a variety of physiological responses including an increase in reactive oxygen species (ROS) production. The unpaired electron on oxygen is extremely reactive. Oxygen intermediates like superoxide, peroxide and hydroxyl group are ROS and promote oxidation reactions of biomolecules such as proteins. ROS can affect all muscle types. For example, in cardiac muscle oxidative stress is linked to heart failure (2). The ROS induced malfunction in the muscle tissue is caused partially by defects in contractile proteins that cause muscle contraction, myosin and actin (1, 2).

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Apr 15th, 3:30 PM Apr 15th, 4:30 PM

Myosin Oxidation and Effects on Magnesium and Actin Binding: Actomyosin

Muscles are responsible for producing force throughout the human body. Muscle tissue is divided into three general types: skeletal, cardiac and smooth muscle. Our muscles are prime targets of oxidative stress as they must respond effectively to influences such as exercise, hormonal changes, development and aging (1). Repetitive muscle contractions lead to a variety of physiological responses including an increase in reactive oxygen species (ROS) production. The unpaired electron on oxygen is extremely reactive. Oxygen intermediates like superoxide, peroxide and hydroxyl group are ROS and promote oxidation reactions of biomolecules such as proteins. ROS can affect all muscle types. For example, in cardiac muscle oxidative stress is linked to heart failure (2). The ROS induced malfunction in the muscle tissue is caused partially by defects in contractile proteins that cause muscle contraction, myosin and actin (1, 2).