Subcellular Localization of FAM171B in Endosomes of Neurons

Presenter Information

Emily Gregersen, Minnesota State University, Mankato
Jenny Vetter, Minnesota State University, Mankato
Sheebong Zama-Chi, Minnesota State University, Mankato

Location

CSU Ballroom

Start Date

12-4-2022 2:00 PM

End Date

12-4-2022 3:30 PM

Student's Major

Biological Sciences

Student's College

Science, Engineering and Technology

Mentor's Name

Geoffrey Goellner

Mentor's Department

Biological Sciences

Mentor's College

Science, Engineering and Technology

Description

FAM171B is a novel protein containing a polyglutamine (polyQ) tract. Polyglutamine tracts in proteins are linked to neurodegenerative diseases such as Spinocerebellar Ataxia and Huntington’s disease. Not much is currently known about novel protein FAM171B and its normal function within cells. Using cell biology techniques such as transfection and immunofluorescence, we observed the location of FAM171B with relationship to late endosomes. Our research results suggest that FAM171B and late endosomes are found in the same areas of the cell but did not definitively show overlap of FAM171B and late endosomes. These experiments allow us to learn more about the normal function of FAM171B, which will further the studying of FAM171B and its relationship with neurodegenerative diseases.