Abstract

Proteins containing polyglutamine (polyQ) tracts within their primary amino acid sequence are particularly interesting because expansion mutation within them has been shown to underlie a growing list of severe neurodegenerative disorders including Huntington's Disease and several types of Spinocerebellar Ataxias. FAM171B is a novel polyQ protein that was originally identified via large scale sequencing efforts. However, to date, very little is known regarding its normal cellular function and expression pattern. In this study, in situ hybridization was utilized to assess whether FAM171B is expressed in developing (postnatal days 7, 21, 42) and adult mouse brains. The results of the experiments performed suggest that FAM171B is indeed expressed in the brain, with pronounced expression in the hippocampus, Purkinje cells of the cerebellum, and cerebral cortex. Given these findings, FAM171B should be considered a candidate gene for exploration of molecularly uncharacterized neurodegenerative diseases.

Advisor

Geoffrey Goellner

First Committee Member

David Sharlin

Second Committee Member

Rachel Cohen

Date of Degree

2017

Language

english

Document Type

Thesis

Degree

Master of Science (MS)

Department

Biological Sciences

College

Science, Engineering and Technology

Creative Commons License

Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License
This work is licensed under a Creative Commons Attribution-Noncommercial-No Derivative Works 4.0 License.

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