Production of [17F]CH3F(t1/2=65s), an Improved PET Tracer for rCBF Measurement

Authors

Todd E. Barnhart, University of Wisconsin - Madison
Alexander K. Converse, University of Wisconsin - Madison
K. A. Dabbs, University of Wisconsin - MadisonFollow
M. J. Schueller, University of Wisconsin - MadisonFollow
Charles K. Stone, University of Wisconsin - MadisonFollow
Robert J. Nickles, University of Wisconsin - Madison
Andrew D. Roberts, Minnesota State University - MankatoFollow

Document Type

Article

Publication Date

4-2005

Abstract

Production of ¹⁷F (t1/2=65s) in the form of [¹⁷F] F₂ has been achieved using both the ²⁰Ne(p,α)¹⁷F and ¹⁶O(d,n)¹⁷F reactions with 11 MeV protons and 6 MeV deuterons, respectively. Yields have proven suitable for subsequent radiosynthesis of the blood flow tracer, [¹⁷F]CH₃F (>60 mCi in saline), currently in use for fast repetition human studies of regional cerebral blood flow with positron emission tomography. Thick target yields of 15 mCi/μA for protons and 44 mCi/μA for deuterons have been measured for [¹⁷F]F₂.

Department

Physics and Astronomy

Publication Title

Applied Radiation and Isotopes

Recommended Citation

T.E. Barnhart, A.K. Converse, K.A. Dabbs, M.J. Schueller, C.K. Stone, R.J. Nickles, and A.D. Roberts. (2005). Production of [17F]CH3F(t1/2=65s), an Improved PET Tracer for rCBF Measurement. Applied Radiation and Isotopes, 62(4), 525-532.

DOI

10.1016/j.apradiso.2004.08.044

Link to Publisher Version (DOI)

https://doi.org/10.1016/j.apradiso.2004.08.044

Publisher's Copyright and Source

Copyright © 2004 Elsevier Ltd. Article published by Elsevier in Applied Radiation and Isotopes, volume 62, issue number 4, April 2005, pages 525-532. Available online on September 21, 2004: https://doi.org/10.1016/j.apradiso.2004.08.044