Aromatic L‐Amino Acid Decarboxylase (AAAD) Activity in Rhesus Macaque Striatum After MAO‐B Inhibition by Ro 16‐6491
Document Type
Article
Publication Date
4-2005
Abstract
The aromatic L-amino acid decarboxylase (AAAD) (EC 4.1.1.28) enzyme converts L-DOPA to dopamine and is critical in dopamine replacement therapy in Parkinson’s disease (PD). Following stimulated release, the action of synaptic dopamine is terminated by neuronal reuptake and deamination by monoamine oxidase (MAO). While MAO inhibition is known to downregulate tyrosine hydroxylase, the rate-limiting enzyme in dopamine synthesis (Lamensdorf and Finberg, 1997), the effect of MAO inhibition on AAAD is unclear. There are two MAO subtypes based on substrate and inhibitor specificity, MAO-A and MAO-B (Kinemuchi et al., 1984). Dopamine is effectively deaminated by both subtypes, but MAO-B has higher activity than MAO-A in the primate striatum, suggesting that MAO-B plays a greater role than MAO-A in striatal dopamine metabolism in primates (Paterson et al., 1995). By slowing dopamine degradation and maximizing L-DOPA efficacy, MAO-B inhibitors may be useful in PD therapy, as suggested by Napolitano et al. (1995).
Publication Title
Synapse
Recommended Citation
O.T. DeJesus, L.G. Flores, A.D. Roberts, D.W. Dick, R.M. Bartlett, D. Murali, and R.J. Nickles. (2005). Aromatic L‐Amino Acid Decarboxylase (AAAD) Activity in Rhesus Macaque Striatum After MAO‐B Inhibition by Ro 16‐6491. Synapse, 56(1), 54-56.
DOI
10.1002/syn.20119
Link to Publisher Version (DOI)
Publisher's Copyright and Source
Copyright © 2005 Wiley-Liss, Inc. Article published by John Wiley & Sons in Synapse, volume 56, issue number 1, April 2005, pages 54-56. Available online on February 7, 2005: http://dx.doi.org/10.1002/syn.20119
