[11C]raclopride Imaging of Dopamine Release in Rhesus Monkeys

Authors

Alexander K. Converse, University of Wisconsin - Madison
Todd E. Barnhart, University of Wisconsin - Madison
Corinne B. Dallas, University of Wisconsin - Madison
Salma Jivan, University of British Columbia
Julie A. Larson, University of Wisconsin - MadisonFollow
Terrence R. Oakes, University of Wisconsin - Madison
Andrew D. Roberts, Minnesota State University - MankatoFollow
Thomas J. Ruth, University of British ColumbiaFollow
Nicholas T. Vandehey, University of Wisconsin - MadisonFollow
Mary L. Schneider, University of Wisconsin - Madison

Document Type

Conference Abstract

Publication Date

2005

Abstract

For a variety of purposes we have begun implementation of a PET method for studying dopamine release. We used the dopamine D2-type receptor antagonist [11C]raclopride to study dopamine function in the rhesus monkey brain in response to an amphetamine challenge. [11C]raclopride is susceptible to competition from endogenous dopamine, whereby dopamine released into extracellular space reduces the number of binding sites available for the tracer.

Department

Physics and Astronomy

Publication Title

Journal of Cerebral Blood Flow & Metabolism

Recommended Citation

A.K. Converse, T.E. Barnhart, C.B. Dallas, S. Jivan, J.A. Larson, T.R. Oakes, A.D. Roberts, T.J. Ruth, N.T. Vandehey, and M.L. Schneider. (2005). [11C]raclopride Imaging of Dopamine Release in Rhesus Monkeys. Journal of Cerebral Blood Flow & Metabolism, 25(S1), S647.

DOI

10.1038/sj.jcbfm.9591524.0647

Link to Publisher Version (DOI)

https://doi.org/10.1038/sj.jcbfm.9591524.0647

Publisher's Copyright and Source

Copyright © 2005 International Society for Cerebral Blood Flow & Metabolism. Abstract published by Nature Publishing Group in Journal of Cerebral Blood Flow & Metabolism, volume 25, supplement 1, 2005, page S647. Available online on August 30, 2005: https://doi.org/10.1038/sj.jcbfm.9591524.0647