Expression of Total Fibronectin Protein in Spontaneously Hypertensive Rat Aorta and Atria as a Function of Age, Gender, and Exercise

Location

CSU

Student's Major

Chemistry and Geology

Student's College

Science, Engineering and Technology

Mentor's Name

Theresa Salerno

Mentor's Department

Chemistry and Geology

Mentor's College

Science, Engineering and Technology

Description

Fibronectin (FN) is a large glycoprotein dimer (500 kDa) that exists in either plasma or the extracellular matrix. The two monomer chains are similar (~250 kDa each) and are linked together by disulFide bonds. FN has multiple functions and is found in many different tissues and organs. Previous research has shown that there is a relationship between hypertension and age with respect to expression of FN in spontaneously hypertensive rats (SHR). This research studied the expression of total FN protein in SHR aorta and atria as a function of age, gender, and exercise. Protein was extracted from rat aorta and atria and total protein was measured. The Western blot technique was used to determine the amount of total FN present in each specific variable via chemiluminescence and densitometry. The difference in total FN protein will be discussed.

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Expression of Total Fibronectin Protein in Spontaneously Hypertensive Rat Aorta and Atria as a Function of Age, Gender, and Exercise

CSU

Fibronectin (FN) is a large glycoprotein dimer (500 kDa) that exists in either plasma or the extracellular matrix. The two monomer chains are similar (~250 kDa each) and are linked together by disulFide bonds. FN has multiple functions and is found in many different tissues and organs. Previous research has shown that there is a relationship between hypertension and age with respect to expression of FN in spontaneously hypertensive rats (SHR). This research studied the expression of total FN protein in SHR aorta and atria as a function of age, gender, and exercise. Protein was extracted from rat aorta and atria and total protein was measured. The Western blot technique was used to determine the amount of total FN present in each specific variable via chemiluminescence and densitometry. The difference in total FN protein will be discussed.