The Effect of Chronic Exercise on Vascular and Kidney Responses in the Spontaneously Hypertensive Rat

Location

CSU 253

Start Date

24-4-2006 10:30 AM

End Date

24-4-2006 12:00 PM

Student's Major

Biological Sciences

Student's College

Science, Engineering and Technology

Mentor's Name

Penny Knoblich

Mentor's Department

Biological Sciences

Mentor's College

Science, Engineering and Technology

Description

Hypertension is among the leading causes of cardiovascular disease, with 65 million Americans suffering from the vascular disorder. Hypertension is believed to result, in part, by the kidney's failure to remove excess sodium and water from the body, as blood pressure rises. Regular exereise has been proven to reduce blood pressure in both humans and rats by reducing the development of atherosclerotic plaques, body weight, and resting heart rate, and alter hormone levels. The effect of exercise on kidney sodium excretion in response to a rise in blood pressure, has not previously been examined. Methods: Thirty male spontaneously hypertensive rats (SHR) will be randomly placed into one of the following groups: Exereise (given an exercise wheel from weaning to 12-14 weeks of age, or Sedentary (no exercise). Exereise time and running distance will be recorded daily. At 14- weeks of age, rats will be anesthetized (Inactin, lOOmg/kg). A breathing tube will be placed in the trachea, and cannulas will be inserted into the carotid artery (to monitor blood pressure and heart rate), the jugular vein (to infuse saline to maintain fluid balance), and into the bladder for urine collection. After a baseline 15-minute period which includes a urine collection, blood pressure will be artificially raised by tying off the celiac, mesenteric, and lower abdominal aorta. Blood pressure will be monitored and urine collected during 3 additional 15-minute periods. Urine will be analyzed for sodium excretion, and data will be compared between sedentary and exercise rats.

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Apr 24th, 10:30 AM Apr 24th, 12:00 PM

The Effect of Chronic Exercise on Vascular and Kidney Responses in the Spontaneously Hypertensive Rat

CSU 253

Hypertension is among the leading causes of cardiovascular disease, with 65 million Americans suffering from the vascular disorder. Hypertension is believed to result, in part, by the kidney's failure to remove excess sodium and water from the body, as blood pressure rises. Regular exereise has been proven to reduce blood pressure in both humans and rats by reducing the development of atherosclerotic plaques, body weight, and resting heart rate, and alter hormone levels. The effect of exercise on kidney sodium excretion in response to a rise in blood pressure, has not previously been examined. Methods: Thirty male spontaneously hypertensive rats (SHR) will be randomly placed into one of the following groups: Exereise (given an exercise wheel from weaning to 12-14 weeks of age, or Sedentary (no exercise). Exereise time and running distance will be recorded daily. At 14- weeks of age, rats will be anesthetized (Inactin, lOOmg/kg). A breathing tube will be placed in the trachea, and cannulas will be inserted into the carotid artery (to monitor blood pressure and heart rate), the jugular vein (to infuse saline to maintain fluid balance), and into the bladder for urine collection. After a baseline 15-minute period which includes a urine collection, blood pressure will be artificially raised by tying off the celiac, mesenteric, and lower abdominal aorta. Blood pressure will be monitored and urine collected during 3 additional 15-minute periods. Urine will be analyzed for sodium excretion, and data will be compared between sedentary and exercise rats.

Recommended Citation

Borg, Cassandra M. and Chris Schmitz. "The Effect of Chronic Exercise on Vascular and Kidney Responses in the Spontaneously Hypertensive Rat." Undergraduate Research Symposium, Mankato, MN, April 24, 2006.
https://cornerstone.lib.mnsu.edu/urs/2006/oral-session-D/2