Identification and Structural Characterization of the Major DNA-DNA Cross-Links of Anti-Cancer Agent Thiophene NCS 652287

Location

CSU North Ballroom

Start Date

25-4-2006 10:00 AM

End Date

25-4-2006 12:00 PM

Student's Major

Chemistry and Geology

Student's College

Science, Engineering and Technology

Mentor's Name

Danae R. Quirk Dorr

Mentor's Department

Chemistry and Geology

Mentor's College

Science, Engineering and Technology

Description

Activated thiophene of NCS 652287 was synthesized using methodology cited in the literature for chemically similar thiophene derivatives, specifically 2,2': 5',2"-terthiophene. The activated thiophene is proposed to fatally cross-link DNA in cancer cells and will be tested using specific DNA nucleobases. Thiophene derivatives have also been shown to have anti-microbial and anti-viral properties, as reported in the literature. These elements make activated thiophene derivative essential in the development of anti-cancer treatments.

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Apr 25th, 10:00 AM Apr 25th, 12:00 PM

Identification and Structural Characterization of the Major DNA-DNA Cross-Links of Anti-Cancer Agent Thiophene NCS 652287

CSU North Ballroom

Activated thiophene of NCS 652287 was synthesized using methodology cited in the literature for chemically similar thiophene derivatives, specifically 2,2': 5',2"-terthiophene. The activated thiophene is proposed to fatally cross-link DNA in cancer cells and will be tested using specific DNA nucleobases. Thiophene derivatives have also been shown to have anti-microbial and anti-viral properties, as reported in the literature. These elements make activated thiophene derivative essential in the development of anti-cancer treatments.

Recommended Citation

Werner, Stacey. "Identification and Structural Characterization of the Major DNA-DNA Cross-Links of Anti-Cancer Agent Thiophene NCS 652287." Undergraduate Research Symposium, Mankato, MN, April 25, 2006.
https://cornerstone.lib.mnsu.edu/urs/2006/poster-session-D/3