Identification and Structural Characterization of the Major DNA-DNA Cross-Links of Anti-Cancer Agent Thiophene NCS 652287
Location
CSU North Ballroom
Start Date
25-4-2006 10:00 AM
End Date
25-4-2006 12:00 PM
Student's Major
Chemistry and Geology
Student's College
Science, Engineering and Technology
Mentor's Name
Danae R. Quirk Dorr
Mentor's Department
Chemistry and Geology
Mentor's College
Science, Engineering and Technology
Description
Activated thiophene of NCS 652287 was synthesized using methodology cited in the literature for chemically similar thiophene derivatives, specifically 2,2': 5',2"-terthiophene. The activated thiophene is proposed to fatally cross-link DNA in cancer cells and will be tested using specific DNA nucleobases. Thiophene derivatives have also been shown to have anti-microbial and anti-viral properties, as reported in the literature. These elements make activated thiophene derivative essential in the development of anti-cancer treatments.
Identification and Structural Characterization of the Major DNA-DNA Cross-Links of Anti-Cancer Agent Thiophene NCS 652287
CSU North Ballroom
Activated thiophene of NCS 652287 was synthesized using methodology cited in the literature for chemically similar thiophene derivatives, specifically 2,2': 5',2"-terthiophene. The activated thiophene is proposed to fatally cross-link DNA in cancer cells and will be tested using specific DNA nucleobases. Thiophene derivatives have also been shown to have anti-microbial and anti-viral properties, as reported in the literature. These elements make activated thiophene derivative essential in the development of anti-cancer treatments.
Recommended Citation
Werner, Stacey. "Identification and Structural Characterization of the Major DNA-DNA Cross-Links of Anti-Cancer Agent Thiophene NCS 652287." Undergraduate Research Symposium, Mankato, MN, April 25, 2006.
https://cornerstone.lib.mnsu.edu/urs/2006/poster-session-D/3
