Mathematical Modeling of Glycolysis Metabolic Pathway Affected by a Pyruvate Kinase Deficiency
Location
CSU Ballroom
Start Date
9-4-2012 10:00 AM
End Date
9-4-2012 11:30 AM
Student's Major
Chemistry and Geology
Student's College
Science, Engineering and Technology
Mentor's Name
Namyong Lee
Mentor's Department
Chemistry and Geology
Mentor's College
Science, Engineering and Technology
Description
Glycolysis is a pathway in all cells that metabolizes glucose to pyruvate and it produces limited amounts of usable energy as ATPs. The different enzymes involved in glycolysis act as kinases, mutases, and dehydrogenases, cleaving enzymes, isomerases or enolases. A pyruvate kinase is the last enzymatic reaction in glycolysis and yields one molecular of pyruvate and one molecular of ATP. When the pyruvate kinase is deficient in the red blood cell, it prevents the cell from producing sufficient amounts of ATP for cell survival.
Mathematical model of glycolysis in human proposed the influence of the key enzymes on the glycolysis energy metabolism. In particular, flux rate and metabolism concentration for both normal functions of the pyruvate kinase enzyme and defective of the pyruvate kinase enzyme were analyzed through the mathematical model.
The steady-state of concentration of the some glycolytic metabolism and glycolytic flux rate depended on the rate constant ATP consuming reaction for normal control and the deficiency and it was calculated through mathematical model.
The mathematical model of the pyruvate kinase deficiency leaded to understand glycolysis metabolic regulation cause by enzymatic activity.
Mathematical Modeling of Glycolysis Metabolic Pathway Affected by a Pyruvate Kinase Deficiency
CSU Ballroom
Glycolysis is a pathway in all cells that metabolizes glucose to pyruvate and it produces limited amounts of usable energy as ATPs. The different enzymes involved in glycolysis act as kinases, mutases, and dehydrogenases, cleaving enzymes, isomerases or enolases. A pyruvate kinase is the last enzymatic reaction in glycolysis and yields one molecular of pyruvate and one molecular of ATP. When the pyruvate kinase is deficient in the red blood cell, it prevents the cell from producing sufficient amounts of ATP for cell survival.
Mathematical model of glycolysis in human proposed the influence of the key enzymes on the glycolysis energy metabolism. In particular, flux rate and metabolism concentration for both normal functions of the pyruvate kinase enzyme and defective of the pyruvate kinase enzyme were analyzed through the mathematical model.
The steady-state of concentration of the some glycolytic metabolism and glycolytic flux rate depended on the rate constant ATP consuming reaction for normal control and the deficiency and it was calculated through mathematical model.
The mathematical model of the pyruvate kinase deficiency leaded to understand glycolysis metabolic regulation cause by enzymatic activity.
Recommended Citation
Kwom, Yonghwa. "Mathematical Modeling of Glycolysis Metabolic Pathway Affected by a Pyruvate Kinase Deficiency." Undergraduate Research Symposium, Mankato, MN, April 9, 2012.
https://cornerstone.lib.mnsu.edu/urs/2012/poster-session-A/36
